Table 2.
Spearman partial correlation among glycated hemoglobin A1c and selected continuous glucose monitoring metrics during pregnancy and postpartum
| During pregnancy | HbA1c | TIR (3.5-7.8) | TIR (3.9-10.0) | TBR (3.5) | TBR (3.0) | TAR (7.8) | TAR (10.0) | Mean glucose | AUC > 7.8 | HBGI | LBGI |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TIR (3.5-7.8 mmol/L) | –0.429 | ||||||||||
| TIR (3.9-10.0 mmol/L) | –0.316 | 0.727 | |||||||||
| TBR (< 3.5 mmol/L) | 0.034 | –0.191 | |||||||||
| TBR (< 3.0 mmol/L) | 0.019 | –0.255 | –0.581 | 0.829 | |||||||
| TAR (> 7.8 mmol/L) | 0.435 | –0.952 | –0.551 | –0.035 | 0.042 | ||||||
| TAR (> 10.0 mmol/L) | 0.365 | –0.848 | –0.686 | 0.050 | 0.113 | 0.869 | |||||
| Mean glucose, mg/dL | 0.405 | –0.763 | –0.281 | –0.322 | –0.205 | 0.883 | 0.763 | ||||
| AUC > 7.8 mmol/L | 0.391 | –0.925 | –0.631 | 0.024 | 0.101 | 0.959 | 0.951 | 0.851 | |||
| HBGI | 0.407 | –0.930 | –0.601 | –0.003 | 0.078 | 0.970 | 0.932 | 0.881 | 0.995 | ||
| LBGI | –0.114 | 0.095 | –0.414 | 0.860 | 0.709 | –0.304 | –0.154 | –0.613 | –0.217 | –0.257 | |
| HbA1c, % | 1.000 | –0.429 | –0.316 | 0.034 | 0.019 | 0.435 | 0.365 | 0.405 | 0.391 | 0.407 | –0.114 |
| Postpartum | HbA 1c | TIR (3.5-7.8) | TIR (3.9-10.0) | TBR (3.5) | TBR (3.0) | TAR (7.8) | TAR (10.0) | Mean glucose | AUC > 7.8 | HBGI | LBGI |
| TIR (3.5-7.8 mmol/L) | –0.766 | ||||||||||
| TIR (3.9-10.0 mmol/L) | –0.574 | 0.746 | |||||||||
| TBR (< 3.5 mmol/L) | –0.127 | 0.137 | –0.298 | ||||||||
| TBR (< 3.0 mmol/L) | –0.196 | 0.023 | –0.255 | 0.854 | |||||||
| TAR (> 7.8 mmol/L) | 0.739 | –0.964 | –0.617 | –0.336 | –0.208 | ||||||
| TAR (> 10.0 mmol/L) | 0.675 | –0.927 | –0.767 | –0.206 | –0.097 | 0.925 | |||||
| Mean glucose, mg/dL | 0.664 | –0.898 | –0.520 | –0.463 | –0.284 | 0.956 | 0.902 | ||||
| AUC > 7.8 mmol/L | 0.702 | –0.940 | –0.747 | –0.197 | –0.089 | 0.940 | 0.985 | 0.919 | |||
| HBGI | 0.707 | –0.944 | –0.736 | –0.199 | –0.080 | 0.944 | 0.980 | 0.922 | 0.998 | ||
| LBGI | –0.273 | 0.380 | –0.117 | 0.924 | 0.708 | –0.560 | -0.401 | –0.677 | –0.401 | –0.406 | |
| HbA1c, % | 1.000 | –0.766 | -0.574 | –0.127 | –0.196 | 0.739 | 0.675 | 0.664 | 0.702 | 0.707 | –0.273 |
Abbreviations: AUC, area under the curve; CGMS, continuous glucose monitoring system; CV, coefficient of variation; HbA1c, glycated hemoglobin A1c; HBGI, high blood glucose indices; , LBGI, low blood glucose indices; MAGE, mean amplitude of glycemic excursions; TAR, time above range; TBR, time below range; TIR, time in range.