Table 3.

Group differences in white matter microstructure outcomes per white matter tract in congenital adrenal hyperplasia and control youth

Diffusion tensor imaging outcomes
Tracts	Fractional anisotropy			Mean diffusivity			Radial diffusivity			Axial diffusivity
	Estimates	CI	P	Estimates	CI	P	Estimates	CI	P	Estimates	CI	P
Anterior commissure	0.003	−0.01-0.02	0.71	−0.000001	−0.00001-0.00001	0.95	−0.000001	−0.00002-0.00001	0.74	−0.000002	−0.00001-0.00002	0.70
Ventral amygdalofugal	0.004	−0.005-0.01	0.38	0.000003	−0.000009-0.00002	0.59	−0.0000008	−0.00001-0.00001	0.91	0.00001	−0.000002-0.00003	0.10
Cingulum	−0.005	−0.02-0.005	0.33	−0.000008	−0.00002-0.000003	0.14	−0.000005	−0.00002-0.000008	0.47	−0.00001	−0.00003-0.0000002	0.047
Fornix	0.02	0.009-0.03	0.0003*	−0.00005	−0.00009-0.00002	0.01*	−0.00006	−0.00009-0.00002	0.001*	−0.00004	−0.00008-0.000002	0.06
Stria terminalis	0.02	0.007-0.03	0.002*	−0.00001	−0.00004-0.00002	0.46	−0.00003	−0.00006-0.000006	0.11	0.00002	−0.00002-0.00005	0.38
Uncinate fasciculus	0.005	−0.002-0.01	0.12	0.0000007	−0.000007-0.000008	0.85	−0.000003	−0.00001-0.000006	0.46	0.000009	−0.000001-0.00002	0.09
Neurite orientation dispersion density index outcomes
	Neurite density index			Isotropic component			Orientation dispersion index
Tracts	Estimates	CI	P-value	Estimates	CI	P-value	Estimates	CI	P-value
Anterior commissure	−0.006	−0.02-0.004	0.21	−0.005	−0.01-0.0006	0.081	−0.006	−0.01-0.003	0.167
Ventral amygdalofugal	−0.005	−0.01-0.003	0.22	0.0004	−0.005-0.006	0.887	−0.006	−0.01-0.0004	0.037
Cingulum	−0.007	−0.02-0.003	0.17	−0.007	−0.02-0.001	0.089	0.0003	−0.006-0.006	0.918
Fornix	−0.0006	−0.01-0.01	0.92	−0.03	−0.05-0.005	0.015	−0.007	−0.01-0.0009	0.025
Stria terminalis	0.0004	−0.01-0.01	0.95	−0.006	−0.03-0.01	0.512	−0.012	−0.02-0.005	0.002*
Uncinate fasciculus	−0.001	−0.009-0.007	0.79	−0.0009	−0.004-0.003	0.593	−0.006	−0.01-0.001	0.015

Beta estimates, 95% CI, and P-values for group differences for DTI and NODDI outcomes. Bold values reflect P < 0.05 uncorrected, * denotes P-value remains significant after multiple comparison correction. For dichotomous grouping variable, congenital adrenal hyperplasia is the reference group (coded = 0 vs controls = 1).