Table 2.
Geometric mean AMH concentration (pmol/L) adjusted for risk factors by which AMH concentrations vary across levels
| Age- and cohort-adjusteda | Age- and cohort-adjusted in dataset with no missing covariatesb | Fully adjusted for each of the other covariates, age, and cohortc | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Geo mean | 95% CI | P value | N | Geo mean | 95% CI | P value | N | Geo mean | 95% CI | P value | |
| Body mass index, kg/m2 | <0.0001 | <0.0001 | <0.0001 | |||||||||
| <18.5 | 69 | 1.98 | (1.42-2.77) | 62 | 2.35 | (1.66-3.31) | 62 | 2.20 | (1.58-3.08) | |||
| 18.5-24.9 | 2197 | 2.79 | (2.62-2.97) | 2057 | 2.88 | (2.71-3.08) | 2057 | 2.83 | (2.65-3.01) | |||
| 25-29.9 | 944 | 2.75 | (2.49-3.03) | 881 | 2.80 | (2.53-3.09) | 881 | 2.85 | (2.57-3.15) | |||
| 30-34.9 | 345 | 2.18 | (1.85-2.58) | 325 | 2.20 | (1.85-2.62) | 325 | 2.31 | (1.95-2.75) | |||
| 35+ | 255 | 1.72 | (1.39-2.13) | 243 | 1.87 | (1.51-2.31) | 243 | 1.97 | (1.59-2.43) | |||
| Age at menarched | <0.0001 | <0.0001 | 0.0002 | |||||||||
| 9-10 | 305 | 1.98 | (1.65-2.37) | 280 | 2.02 | (1.67-2.44) | 280 | 2.09 | (1.73-2.52) | |||
| 11 | 581 | 2.53 | (2.24-2.87) | 559 | 2.63 | (2.32-2.99) | 559 | 2.71 | (2.39-3.07) | |||
| 12 | 1016 | 2.39 | (2.17-2.62) | 949 | 2.43 | (2.21-2.68) | 949 | 2.44 | (2.22-2.70) | |||
| 13 | 1099 | 2.78 | (2.55-3.04) | 1025 | 2.86 | (2.61-3.14) | 1025 | 2.86 | (2.61-3.13) | |||
| 14 | 459 | 3.21 | (2.81-3.68) | 429 | 3.35 | (2.91-3.85) | 429 | 3.25 | (2.83-3.73) | |||
| 15+ | 351 | 2.89 | (2.46-3.39) | 326 | 3.09 | (2.63-3.63) | 326 | 2.98 | (2.53-3.51) | |||
| Parityd | 0.0008 | 0.0037 | 0.0284 | |||||||||
| Nulliparous | 865 | 2.32 | (2.10-2.56) | 809 | 2.45 | (2.22-2.72) | 809 | 2.52 | (2.27-2.79) | |||
| 1 | 514 | 2.44 | (2.12-2.80) | 491 | 2.49 | (2.16-2.86) | 491 | 2.52 | (2.19-2.90) | |||
| 2 | 1404 | 2.68 | (2.48-2.91) | 1340 | 2.75 | (2.54-2.99) | 1340 | 2.74 | (2.53-2.97) | |||
| 3 | 709 | 2.88 | (2.57-3.22) | 678 | 2.95 | (2.63-3.31) | 678 | 2.90 | (2.59-3.25) | |||
| 4 or more | 266 | 2.96 | (2.45-3.57) | 250 | 3.06 | (2.52-3.71) | 250 | 2.94 | (2.43-3.55) | |||
| Hysterectomy and/or oophorectomy | 0.0008 | 0.0066 | 0.0084 | |||||||||
| No | 3576 | 2.69 | (2.56-2.83) | 3349 | 2.76 | (2.62-2.90) | 3349 | 2.76 | (2.62-2.90) | |||
| Hysterectomy without oophorectomy | 107 | 1.78 | (1.22-2.59) | 96 | 1.83 | (1.24-2.70) | 96 | 1.86 | (1.26-2.74) | |||
| Partial oophorectomy | 133 | 1.89 | (1.42-2.50) | 123 | 2.12 | (1.58-2.84) | 123 | 2.13 | (1.60-2.85) | |||
| Oral contraceptive use | <0.0001 | <0.0001 | <0.0001 | |||||||||
| Never | 911 | 2.65 | (2.40-2.93) | 854 | 2.77 | (2.50-3.07) | 854 | 2.75 | (2.49-3.04) | |||
| Former | 2639 | 2.72 | (2.57-2.88) | 2521 | 2.78 | (2.62-2.95) | 2521 | 2.78 | (2.63-2.95) | |||
| Current | 184 | 1.60 | (1.26-2.03) | 172 | 1.61 | (1.26-2.06) | 172 | 1.60 | (1.24-2.06) | |||
| Benign breast disease | 0.0314 | 0.0201 | 0.0193 | |||||||||
| No | 3128 | 2.55 | (2.42-2.69) | 2934 | 2.63 | (2.49-2.78) | 2934 | 2.63 | (2.49-2.77) | |||
| Yes | 633 | 2.94 | (2.60-3.33) | 603 | 3.08 | (2.71-3.49) | 603 | 3.08 | (2.71-3.49) | |||
| Smoking | 0.0103 | 0.0087 | 0.0058 | |||||||||
| Never | 2340 | 2.78 | (2.62-2.96) | 2275 | 2.84 | (2.67-3.02) | 2275 | 2.85 | (2.68-3.04) | |||
| Former | 912 | 2.52 | (2.27-2.79) | 894 | 2.59 | (2.34-2.87) | 894 | 2.55 | (2.31-2.82) | |||
| Current | 412 | 2.21 | (1.92-2.55) | 399 | 2.23 | (1.93-2.58) | 399 | 2.24 | (1.94-2.59) |
a Model adjusted for age, age-squared, and cohort only
b Subjects with missing data on any of the covariates were excluded from this analysis.
c Model adjusted for age, age-squared, and cohort in addition to all other variables in the table.
d Ordered categories of age at menarche and parity were used to estimate P values