Table 1.
Baseline patient characteristics
| Patient characteristics | (n = 75) | |
|---|---|---|
| Age, y | 50 (range 29-65) | |
| Gender, n (%) | ||
| Female | 58 (77.3) | |
| Male | 17 (22.7) | |
| Race, n (%) | ||
| Caucasian | 58 (77.3) | |
| African American | 12 (16.0) | |
| Asian | 3 (4.0) | |
| Hispanic | 2 (2.7) | |
| Clinical measures | ||
| Weight mean, lb (SD) | 180 (40.2) | |
| Cause of hypothyroidism, n (%) | ||
| Autoimmune, Hashimoto | 46 (61.3) | |
| Post-radioiodine, Graves’ disease | 4 (5.3) | |
| Postthyroidectomy | 16 (21.3) | |
| Idiopathic | 9 (12.1) | |
| Biochemical measures, mean (SD) | ||
| Total cholesterol | (<200 mg/dL) | 199 (39.8) |
| LDL cholesterol | (<100 mg/dL) | 128 (36.0) |
| HDL cholesterol | (>60 mg/dL) | 61.0 (18.6) |
| Triglyceride | (<150 mg/dL) | 106 (60.7) |
| Total T3 | (60-181 ng/dL) | 109 (27.3) |
| T3 resin uptake | (22-35%) | 28.0 (3.53) |
| T3 reverse | (11-32 ng/dL) | 19.9 (6.81) |
| TSH | (0.27-4.20 uIU/mL) | 1.77 (1.10) |
| Total T4 | (4.5-12 μg/dL) | 8.21 (2.22) |
| Free T4 | (0.89-1.76 ng/dL) | 1.41 (0.37) |
| Free T4 direct dialysis | (0.8-2.7 ng/dL) | 1.29 (0.38) |
| SHBG | (17-124 nmol/L) | 71.0 (51.7) |
| Leptin | (<60 ng/mL for BMI < 30) | 20.2 (14.9) |
| Prestudy medications, mean (SD), (n) | ||
| LT4 dosage (mcg) | 112.5 (28.7), (n = 64) | |
| DTE dosage (mg) | 71.2 (10.9), (n = 8) | |
| LT4 + LT3 dosage (mcg) | 97.3 (16.2) + 5 (0), (n = 3) |
Abbreviations: DTE, desiccated thyroid extract; HDL, high density lipoprotein; LDL, low density lipoprotein; LT3, liothyronine; LT4, levothyroxine.