Table 4.
Primary and secondary outcomes
| Parameters | LT4 (N = 75) | DTE (N = 75) | LT4 + LT3 (N = 75) | P value |
|---|---|---|---|---|
| Primary outcomes | ||||
| Quality of life and cognition | ||||
| TSQ-36 | 15.9 (7.49) | 14.5 (8.22) | 14.9 (6.67) | 0.357 |
| GHQ-12 | 11.9 (5.13) | 11.7 (6.16) | 11.6 (4.83) | 0.891 |
| BDI | 7.15 (7.11) | 7.09 (8.55) | 7.33 (7.67) | 0.947 |
| AMI | 121 (12.8) | 121 (14.7) | 120 (14.0) | 0.825 |
| VMI | 80.4 (12.1) | 79.8 (8.06) | 81.0 (11.3) | 0.518 |
| VWMI | 116 (14.3) | 115 (18.2) | 117 (17.2) | 0.461 |
| IMI | 99.7 (10.7) | 97.9 (15.4) | 98.0 (15.2) | 0.537 |
| DMI | 101 (12.0) | 101 (10.8) | 100 (16.3) | 0.827 |
| Secondary outcomes | ||||
| Thyroid function tests | ||||
| T3 (60-181 ng/dL) | 103 (22.1) | 155 (48.7) | 132 (33.2) | <0.001 |
| T3 resin | 28.1 (3.48) | 25.8 (4.01) | 26.6 (3.95) | <0.001 |
| T3 reverse | 20.6 (5.60) | 14.4 (5.31) | 16.7 (5.02) | <0.001 |
| TSH | 1.63 (1.28) | 2.34 (1.48) | 1.76 (1.13) | <0.001 |
| Total T4 | 8.46 (2.14) | 5.62 (1.38) | 6.92 (1.62) | <0.001 |
| Free T4 | 1.44 (0.358) | 0.980 (0.673) | 1.21 (0.532) | <0.001 |
| Free T4 direct dialysis | 1.30 (0.292) | 0.828 (0.293) | 1.06 (0.286) | <0.001 |
| Total T4/T3 ratio | 82.1(9.7) | 36.2(2.8) | 52.4 (4.9) | <0.001 |
| Metabolism | ||||
| Weight (lbs) | 181 (38.7) | 180 (40.0) | 178 (43.6) | 0.278 |
| Total cholesterol | 195 (42.5) | 196 (37.1) | 195 (38.2) | 0.85 |
| LDL cholesterol | 130 (35.3) | 127 (33.6) | 126 (35.8) | 0.31 |
| HDL cholesterol | 59.7 (15.6) | 60.5 (18.9) | 60.4 (17.8) | 0.773 |
| Triglyceride | 109 (74.8) | 109 (65.7) | 102 (63.5) | 0.411 |
| SHBG | 72.3 (48.1) | 69.5 (37.9) | 75.0 (45.7) | 0.08 |
| Leptin | 22.1 (17.9) | 21.5 (17.7) | 22.2 (18.6) | 0.826 |
P value reports the results of a linear mixed effects model evaluating the fixed effect of the 3 treatment conditions, using participant as a random effect.
Abbreviations: AMI, auditory memory index; BDI, Beck Depression Inventory; DTE, desiccated thyroid extract; DMI, delayed memory index; GHQ-12, 12-point quality of life general health questionnaire; HDL, high-density lipoprotein; LDL, low-density lipoprotein; IMI, immediate memory index; LT3, liothyronine; LT4, levothyroxine; TSQ-36, 36-point thyroid symptom questionnaire; VMI, visual memory index; VWMI, visual working memory index.