Table 7.

Primary and secondary outcomes based on etiology of hypothyroidism

Parameters	Autoimmune (N = 153)	Nonautoimmune (N = 72)	P value
Primary outcomes
Quality of life and cognition
TSQ-36	14.7 (7.39)	15.9 (7.65)	0.414
GHQ-12	11.6 (5.41)	12.2 (5.34)	0.603
BDI	7.21 (8.00)	7.15 (7.29)	0.974
AMI	123 (13.2)	117 (14.3)	0.0657
VMI	80.1 (10.5)	80.9 (10.9)	0.732
VWMI	117 (16.9)	113 (15.8)	0.279
IMI	98.9 (15.2)	97.6 (10.6)	0.617
DMI	101 (14.1)	98.7 (10.9)	0.314
Secondary outcomes
Thyroid function tests
T3 (60-181 ng/dL)	129 (41.1)	133 (44.2)	0.43
T3 resin (22%-35%)	26.9 (3.67)	26.8 (4.42)	0.953
T3 reverse (11-32 ng)	17.4 (6.27)	16.8 (5.01)	0.538
TSH (.27-4.68 ulU)	2.11 (1.34)	1.49 (1.22)	0.0097
TT4 (4.5-12 mcg/dL	7.15 (2.08)	6.67 (2.09)	0.174
FT4 (.89-1.76 ng)	1.24 (0.655)	1.15 (0.302)	0.481
FT4 direct (.8-2.7 ng/dL)	1.05 (0.326)	1.10 (0.387)	0.313
Metabolism
Weight (lbs)	177 (41.6)	183 (38.5)	0.536
Tot cholesterol	195 (37.8)	196 (42.1)	0.938
LDL	128 (35.5)	127 (33.3)	0.865
HDL	58.2 (15.2)	64.5 (20.7)	0.117
Triglyceride	109 (70.2)	101 (63.0)	0.586
SHBG (17-124 nmol/L)	70.3 (38.6)	76.6 (53.8)	0.551
Leptin	21.4 (17.4)	23.2 (19.3)	0.673

P value reports the results of a linear mixed effects model evaluating the fixed effect of hypothyroidism etiology, adjusted for the 3 treatment conditions, using participant as a random effect.

Abbreviations: AMI, auditory memory index; BDI, Beck Depression Inventory; DTE, desiccated thyroid extract; DMI, delayed memory index; GHQ-12, 12-point quality of life general health questionnaire; HDL, high-density lipoprotein; LDL, low-density lipoprotein; IMI, immediate memory index; LT3, liothyronine; LT4, levothyroxine; TSQ-36, 36-point thyroid symptom questionnaire; VMI, visual memory index; VWMI, visual working memory index.