Table 6.
Mean percentage difference of morning and evening salivary hormone levels in patients with CAH and controls
| Δ mean | Δ hormone levels | ||||
|---|---|---|---|---|---|
| Patients | Controls | Patients | Controls | ||
| Men | 17OHP | 75.8* | 45.1*** | 1353.0 (514.9) | 56.4 (24.3) |
| A4 | 45.2 | 47.4*** | 233.0 (83.1) | 150.9 (34.0) | |
| 11OHA4 | 66.3*** | 82.5*** | 616.4 (250.6) | 696.4 (121.3) | |
| T | 35.7*** | 33.8** | 66.0 (11.1) | 73.0 (20.6) | |
| 11KT | 56.7*** | 63.0*** | 338.6 (124.0) | 248.9 (30.7) | |
| Women | 17OHP | 86.1*** | 12.4 | 1433.0 (614.1) | 0.4 (21.3) |
| A4 | 41.8*** | 26.6* | 133.8 (37.1) | 59.9 (26.1) | |
| 11OHA4 | 47.4*** | 85.9*** | 195.4 (100.1) | 391.5 (70.7) | |
| T | 45.1* | 17.7** | 21.9 (7.9) | 10.4 (15.4) | |
| 11KT | 49.5*** | 76.3*** | 136.4 (41.0) | 130.1 (24.3) |
Presentation of values as percentage difference of mean (Δmean) morning (timepoint 1) and evening (timepoint 5) hormone levels (%). Presentation of difference of hormone levels between timepoints 1 and 5 (Δhormone levels) as mean (SEM) in pg/mL. Linear mixed-effects models with time as fixed and subject as random effects were calculated. P value ≤ 0.01 (*), ≤ 0.001 (**), ≤ 0.0001 (***).
Abbreviations: 11KT, 11-ketotestosterone; 11OHA4, 11β-hydroxyandrostenedione; 17OHP, 17-hydroxyprogesterone; A4, androstenedione; T, testosterone.