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Transient conjugation. Lonapegsomatropin is a long-acting prodrug consisting of the parent drug, unmodified somatropin; an inert carrier; and a proprietary linker that temporarily binds the somatropin and carrier. The carrier has a shielding effect that minimizes renal excretion and receptor-mediated clearance. Following autocleavage of the linker under physiologic conditions, lonapegsomatropin predictably releases somatropin within therapeutic levels over one week.
