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. 2021 Jun 25;106(11):3265–3282. doi: 10.1210/clinem/dgab471

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Heat map of the somatic mutational landscape across the whole-genome sequenced tumor cohort. Each column represents one patient/tumor. Each row represents a mutated gene and the color code represents the mutation type. The top grid displays thyroid-related genes (top 20 COSMIC mutated genes), while the bottom grid displays top mutations called by MutSigCV2 sorted by P value. Cases 202 and 208 are Hürthle cell carcinomas; the remaining 11 cases are widely invasive follicular thyroid carcinomas (wiFTCs).