Table 1.

Laboratory work up for case 1, case 2, and case 3

Biochemical testing	Case 1	Case 2	Case 3	Reference range
Morning cortisol following the 1-mg overnight DST, mcg/dL	2.9	3.3	22	<1.8
ACTH, pg/mL	<5	14	<5	7.2-63
DHEA-S, mcg/dL	26	485	<15	15-200 (case 1); 44-332 (case 2); 18-284 (case 3)
Aldosterone, ng/dL	8	5	4	<21
Plasma renin activity, ng/mL/h	4.1	1.7	<0.6	≤0.6-3
Urine metanephrines, mcg/24 h	-	227	-	<400
Urine normetanephrine, mcg/24 h	-	356	-	<900
Urine free cortisol, mcg/24 h	27	38	389	3.5-45

Abbreviations: DHEA-S, dehydroepiandrosterone sulfate; DST, dexamethasone suppression test.