Figure 3.

Aoah^−/− mice exhibit gut dysbiosis. A: PCA plot of 16S rRNA analyses of fecal stool. Dots represent individual mice; AOAH-deficient mice are shown in blue (n = 5) and wild-type mice are shown in red (n = 5). B: α-diversity as measured by observed operational taxonomic units (OTUs), n = 5 for both groups, *P < 0.05. C: heat map of 16S rRNA analyses of AOAH-deficient (blue) and wild-type (red) fecal stool (n = 5). D: quantification of bacterial phyla using 16S rRNA sequencing in wild-type and AOAH-deficient fecal stool (n = 5). AOAH, acyloxyacyl hydrolase; PCA, principal component analysis.