Fig 5.

UMAP analysis of T-cell and NK cell populations. (A) Ten selected FC, 5 MIS-C, 5 recovery, 5 HC, and 3 MIS-C subjects. MIS-C patients demonstrate increased number of NK cells of 2 phenotypes, indicated by a red arrow and blue arrow in the UMAP of the first MIS-C patients. These cell populations are seen also in MIS-C–like patients. MIS-C patients and FCs showed decreased expression of a third phenotype (green arrow). (B, C) Representative expression of cellular markers from 1 patient with MIS-C (B) and 1 FC (C) demonstrating KLRG1, PD-1, TIGIT, LAG3, TIM3, BTLA, CD161, and CD38. (D) Histogram of clusters indicated on previous diagrams with red arrow and blue arrow, with relative expression levels of KLRG1, TIGIT, CD161, and CD38.