| Study name |
Multi‐arm Optimization of Stroke Thrombolysis (MOST): a single blinded, randomized controlled adaptive, multi‐arm, adjunctive‐thrombolysis efficacy trial in ischemic stroke |
| Methods |
Double‐blinded (participant, outcomes assessor blinded) |
| Participants |
18 years of age and older, acute ischaemic stroke treated with 0.9 mg/kg IV rt‐PA within 3 hours of stroke onset or time last known well, NIHSS score ≥ 6 prior to IV rt‐PA, able to receive assigned study drug within 60 minutes of initiation of IV rt‐PA
Estimated 1200 participants
USA |
| Interventions |
Argatroban: 100 µg/kg bolus followed by 3 µg/kg per minute for 12 hours
Eptifibatide: 135 µg/kg bolus followed by 0.75 µg/kg per minute infusion for 2 hours
Control: placebo |
| Outcomes |
Efficacy: mRS at 90 days |
| Starting date |
15 October 2019 |
| Contact information |
Opeolu Adeoye; adeoyeo@ucmail.uc.edu
Andrew Barreto Andrew; d.barreto@uth.tmc.edu
University of Cincinnati, National Institute of Neurological Disorders and Stroke |
| Notes |
https://clinicaltrials.gov/ct2/show/NCT03735979 |
