NCT04275180.

Study name	Clinical study of argatroban in the treatment of acute progressive ischemic stroke
Methods	Randomised parallel open‐label
Participants	Progress of ischaemic stroke with neurological function deteriorated from 6 hours to 48 hours after onset of the disease, NIHSS score increased by ≥ 2 points Estimated 628 participants China
Interventions	Argatroban on the basis of standard medical treatment Control: standard medical treatment, including routine antiplatelet, blood pressure control, statins to stabilise plaque, etc
Outcomes	Efficacy: mRS at 3 months; NIHSS at 7 days, 1 month, and 3 months Safety: SICH at 7 days, adverse events at 3 months
Starting date	21 March 2020
Contact information	Min Lou, Loumingxc@vip.sina.com, Second Affiliated Hospital, School of Medicine, Zhejiang University
Notes	https://clinicaltrials.gov/ct2/show/study/NCT04275180