Table 1.

Cell Migration and Neuronal Processes Guided by Localized or Enriched BM Cues

Guided cell process/Animal	Localized or enriched BM component/Tissue BM where enriched	Receptor or molecular pathway activated to guide cell	References
Cell invasion through BM/C. elegans larva	UNC-6 (netrin)/uterine vulval connection site	UNC-40 (DCC) receptor	[17,51]
Longitudinal neuronal axon pathfinding/C. elegans larva	Nidogen (may localize ectodomain of transmembrane collagen COL-99)/Sublateral nerves and edges of body wall muscles	Discoidin domain receptor	[20,25,52]
Halting somatic gonad precursor migration/C. elegans embryo	Laminin/Posterior endoderm cells	pathway unknown	[21]
PVD neuron dendrite branching/C. elegans larva	Perlecan and nidogen (may localize UNC-6(netrin))/Fibrous organelles (muscle linkage site to epidermis)	SAX-7 (L1CAM) adhesion molecule and UNC-40 (DCC) receptor	[15,16]
Sematosensory neuron peripheral axon pathfinding/Zebrafish embryo	Heparan sulfate proteoglycan/Skin	LAR receptor tyrosine phosphatase	[22]
Commissural neuron axon crossing/Chick embryo	Cleaved F-spondin/Spinal cord floor plate	pathway unknown	[24]
Commissural neuron axon crossing/Mouse embryo	Glycosylated dystroglycan binding Slit/, Spinal cord floor plate	Robo receptor	[28]
Retinal ganglion cell axon projections/Zebrafish larva	Type IV collagen binding Slit/Surface of optic tectum	Robo receptor	[18]
Renal tubule elongation pathfinding/Drosophila embryo	Type IV collagen (may localize Decapentaplegic (Dpp))/Leading anterior tubule cells	BMP receptor	[19]
Motor axon pathfinding in embryonic ventral nerve cord/Drosophila embryo	Perlecan secreted by motor neurons/Enriched along motor axon trajectories and pathway choice points	Semaphorin-Plexin	[29]
Enteric neural crest-derived cell (ENCDCs) migration/Mouse, chick, zebrafish embryos	Collagen XVIII secreted by ENCDCs at wavefront and agrin secreted by trailing cells/Gut blood vessels	Collagen XVIII pathway unknown, Agrin may signal through dystroglycan receptor	[23,26]
Ventral spinal motor neuron migration/Mouse embryo	Slit gene expressed by spinal cord motor neurons/Spinal cord floor plate	Robo receptor	[27,28]
Neural crest mid-segmental migration & Motor axon outgrowth/Zebrafish embryo	Lh3 glycosyl transferase and presumptive substrate collagen XVIII / Adaxial muscle cells	Pathway unknown	[53,54]