Unadjusted OS (solid lines) and CSS (dotted lines) for patients with metastatic breast cancer from the SEER Program, diagnosed 2010–2016, stratified by the number of metastatic sites: 1 (blue lines), 2 (red lines), 3 (green lines), and ≥ 4 (purple lines). one site = one organ system involved, irrespective of the number of the metastases within that organ system; two sites = two organ systems involved; etc.