Table 3.
Standardized cognitive score by randomization group and age adjusted for repeated measures, order of cognitive test, CVD history, age, sex, race, education, baseline BMI, systolic blood pressure, years from randomization, interaction between age and years from randomization.
Randomization Group | Difference | ||||
---|---|---|---|---|---|
ILI | DSE | ILI-DSE | Randomization *Age | ||
Cognitive Test | Age | LSMEAN ± SE | LSMEAN ± SE | LSMEAN (95% CI) | P-value |
Cognitive Composite | <65 years | −0.12±0.02 | −0.12±0.02 | −0.01(−0.05,0.04) | 0.246 |
65+ years | −0.67±0.04 | −0.73±0.04 | 0.06(−0.04,0.16) | ||
DSC | <65 years | −0.21±0.02 | −0.20±0.02 | −0.00(−0.06,0.06) | 0.605 |
65+ years | −0.77±0.05 | −0.81±0.05 | 0.04(−0.10,0.17) | ||
3MS | <65 years | −0.09±0.02 | −0.09±0.02 | −0.00(−0.06,0.06) | 0.649 |
65+ years | −0.63±0.05 | −0.66±0.05 | 0.04(−0.11,0.18) | ||
Rey AVLT Delayed | <65 years | 0.03±0.02 | 0.04±0.02 | −0.01(−0.07,0.05) | 0.131 |
65+ years | −0.42±0.05 | −0.52±0.05 | 0.11(−0.03,0.24) | ||
Rey AVLT Immed | <65 years | −0.10±0.02 | −0.08±0.02 | −0.02(−0.09,0.04) | 0.077 |
65+ years | −0.66±0.05 | −0.77±0.05 | 0.11(−0.03,0.25) | ||
Stroop | <65 years | −0.19±0.02 | −0.16±0.02 | −0.03(−0.09,0.04) | 0.464 |
65+ years | −0.75±0.06 | −0.78±0.06 | 0.04(−0.12,0.20) | ||
Trails A | <65 years | −0.07±0.02 | −0.07±0.02 | 0.00(−0.06,0.07) | 0.996 |
65+ years | −0.67±0.05 | −0.67±0.05 | 0.00(−0.14,0.14) | ||
Trails B | <65 years | −0.12±0.02 | −0.11±0.02 | −0.02(−0.08,0.05) | 0.722 |
65+ years | −0.72±0.05 | −0.68±0.05 | −0.04(−0.19,0.10) |
Abbreviations: AVLT=Auditory Verbal Learning Test; BMI=body mass index; CVD=cardiovascular disease; DSC=Digit Symbol Coding; DSE=diabetes support and education; ILI=intensive lifestyle intervention; Immed=immediate recall; LSMEAN=least squares mean; 3MS= Modified Mini Mental State Exam; SE=standard error; Trails A=Trail Making Test Part A; Trails B=Trail Making Test Part B