Table 3:

Demographic and clinical characteristics of 10 probands with suspected MODY diagnosis. Participants in bold were found to have a pathogenic variant in the present study.

Case ID	Age at diagnosis (y)	Sex	Race & Ethnicity	Diabetes type per clinical diagnosis	Islet antibodies	Random C-peptide at diagnosis (ng/mL)	Random C-peptide post-diagnosis (ng/mL)	Previously negative MODY panel	Significant past medical history	Family History of Diabetes
1	13.7	M	Hispanic	T1D	Neg x4	0.39	1.66 (1-y pd) and 0.84 (2-year pd)	Athena 5-gene panel		Mother, maternal aunt, MGM, MGF
2	12.7	M	Hispanic	Atypical KPD	Neg x3	1.73	2.92 (3-wk pd)	BGL 25-gene panel		Mother, sister, MGM, PGM
3	12.1	F	Asian	T1D	Neg x4	1.67		Athena 5-gene panel	Pancreatic pseudocyst, necrotizing pancreatitis, hypertriglyceridemia	Mother, father, PGM, MGF
4	6.6	F	Hispanic	Unknown	Neg x4	1.16	0.49 (3-y pd)	Athena 5-gene panel	Depression/anxiety	Mother, sister, MGM
5	15.6	F	Hispanic	Unknown	Neg x4	1.04	0.19 (9-mo pd)	Athena 5-gene panel	Depression/anxiety	Mother, father, sister, MGM, MGF, PGM
6	7.4	F	NHW	T1D	Neg x3	0.21	1.02 (15-mo pd)	Gene Dx 5-gene panel		Mother, MGGM
7	12.3	F	NHW	T1D	Neg x3	2.21		Athena 5-gene panel		Mother, father, PGF, PGGM
8	3.7	M	Hispanic	T1D	Neg x3	0.39	0.62 (4-y pd)	Athena 5-gene panel		MGM, MGF
9	7.7	F	NHW	T1D	Neg x4	0.4	1.5 (3-mo pd)	Athena 10-gene panel		None
10	8.0	M	NHW	T1D	Neg x3	0.67	0.36 (2-y pd)	Athena 5-gene panel		MGM

Abbreviations: y, years; wk, weeks; mo, months; M, male; F, female; NHW, non-Hispanic white; T1D, type 1 diabetes; KPD, ketosis-prone diabetes; pd, post-diagnosis; Neg x4, negative for 4 islet autoantibodies including GAD-65, ICA-512, insulin and ZnT8 autoantibodies; Neg x3, negative for 3 islet autoantibodies including GAD-65, ICA-512 and insulin autoantibody; pd, post-diagnosis; BCM, Baylor Genetics Laboratory; MGM, maternal grandmother; MGF, maternal grandfather; PGM, paternal grandmother; PGF, paternal grandfather; MGGM, maternal great grandmother; PGGM, paternal great grandmother