Table 1.
Patient and Treatment Characteristics and hs-cTnT Comparisons
| Characteristics | No. of Pts (n=225, %) | hs-cTnT baseline (n=158) |
hs-cTnT delta (n=149) |
||
|---|---|---|---|---|---|
| mean (SD) | P | mean (SD) | P | ||
| Age | <0.0001 | 0.683 | |||
| <64 years | 90 (40) | 5.1 (3.7) | 3.0 (4.7) | ||
| ≥64 years | 135 (60) | 10.2 (11.7) | 4.1 (11.3) | ||
| Sex | <0.0001 | 0.455 | |||
| Female | 106 (47) | 6.3 (9.1) | 3.1 (6.5) | ||
| Male | 119 (53) | 9.9 (10.0) | 4.3 (11.6) | ||
| Race | 0.848 | 0.282 | |||
| White | 204 (91) | 8.0 (9.5) | 3.8 (9.4) | ||
| Other | 21 (9) | 10.1 (12.6) | 2.5 (9.1) | ||
| Disease Stage | 0.902 | 0.902 | |||
| II | 18 (8) | 10.7 (11.4) | 3.7 (6.1) | ||
| IIIA | 91 (40) | 7.6 (8.9) | 2.2 (3.9) | ||
| IIIB | 92 (41) | 8.5 (10.1) | 4.6 (12.8) | ||
| IV | 10 (5) | 11.3 (16.8) | 7.3 (14.6) | ||
| Recurrent | 14 (6) | 5.8 (3.5) | 3.9 (7.3) | ||
| Tumor Histology | 0.065 | 0.428 | |||
| Adeno | 118 (52) | 7.4 (8.3) | 4.5 (11.6) | ||
| Squamous | 76 (34) | 7.9 (9.0) | 3.2 (3.7) | ||
| Other | 31 (14) | 12.5 (15.2) | 1.3 (8.1) | ||
| Gross Tumor Volume* | 0.191 | 0.651 | |||
| ≤126.5 cm3 | 147 (65) | 7.4 (7.6) | 4.2 (10.6) | ||
| >126.5 cm3 | 77 (34) | 10.0 (13.1) | 2.5 (6.1) | ||
| Tumor Location | 0.999 | 0.006 | |||
| Left/ Mediastinal | 90 (40) | 7.0 (6.2) | 5.9 (12.1) | ||
| Right | 130 (58) | 9.1 (11.7) | 2.1 (6.6) | ||
| Other | 5 (2) | 5.6 (1.5) | 2.3 (2.7) | ||
| KPS | 0.025 | 0.762 | |||
| <80 | 26 (12) | 17.1 (20.2) | 1.8 (9.4) | ||
| ≥80 | 199 (88) | 7.2 (7.3) | 3.9 (9.3) | ||
| Smoking Status | 0.334 | 0.889 | |||
| Never | 18 (8) | 7.0 (5.9) | 4.0 (6.5) | ||
| Previous | 159 (71) | 8.7 (9.6) | 3.3 (6.1) | ||
| Current | 48 (21) | 7.3 (11.5) | 4.6 (16.3) | ||
| Pre-existing heart disease | 0.0008 | 0.554 | |||
| No | 182 (81) | 7.6 (9.7) | 3.8 (10.0) | ||
| Yes | 43 (19) | 11.1 (9.8) | 2.8 (5.7) | ||
| Modality | 0.622 | 0.088 | |||
| PSPT† | 88 (39) | 9.3 (11.6) | 3.5 (13.0) | ||
| IMRT | 137 (61) | 7.5 (8.3) | 3.8 (5.8) | ||
Abbreviations: Pts, patients; hs-cTnT, high-sensitivity cardiac troponin T; KPS, Karnofsky performance status score; PSPT, passively-scattered proton therapy; IMRT, intensity-modulated (photon) radiation therapy.
*
One patient had no information on gross tumor volume.
†
One patient was grouped in PSPT but was treated with 34 Gy PSPT first and 38 Gy IMRT later