Table 2.

Post-hoc associations between participants’ brain (or behavioral) scores, disease severity, and medication use (categorized by the neurotransmitter target).

	Brain scores		Behavior scores
	r/t	p	r/t	p
Disease severity
Disease duration	0.11	0.334	0.01	0.958
# Hospitalizations	−0.16	0.253	0.16	0.244
Medication use (by target)
Dopaminergic	2.40	0.018	2.10	0.037
Serotonergic	−0.10	0.924	2.61	0.010
Glutamatergic	−0.18	0.860	−0.04	0.969
GABAergic	−0.81	0.417	1.46	0.146
Norepinephrinergic	2.25	0.026	0.89	0.376
Lithium	−1.87	0.064	0.73	0.467
No medication	0.99	0.325	−0.74	0.458
# Meds	−0.12	0.153	0.14	0.090

Pearson correlations (for continuous measures) or t-tests (for categorical measures) were computed across all participants. A higher r value indicates a stronger association between brain (or behavioral) scores and disease severity, while a higher t value indicates higher brain (or behavioral) scores in participants taking the specific medication. Significant correlations or t-tests that survived FDR correction (q > 0.05) are indicated in bold. The same analysis was performed after classifying medication by medication class (see Table S3).