FIG. 1.

(A) Structures of Vav family proteins. The tyrosine residue involved in Vav downmodulation (Y174) is shown. The alternative sequences of Vav2 generated by alternative splicing of its hnRNA are indicated by A, B, and C. Deletions or insertions of sequences found in the CelVav protein are illustrated by using empty spaces and solid boxes, respectively. The lack of the two cysteine residues in the C terminus of the CelVav ZF is indicated by a gray box. SH3L is the region with low resemblance to SH3 domains present in CelVav. (B) Oncogenic mutations found in Vav family members. WT, wild type. An asterisk indicates the Y174F mutation. Amino acid numbers are shown at the bottom of each panel.