FIG. 5.

Schematic representation of thymocyte development. The processes affected by the vav gene knockout are indicated. Defects observed in other signaling proteins involved in the Vav pathways have been included for comparison. Inhibition or upregulation of a given T-cell response is indicated by blunt or sharp arrows, respectively. The α and β subunits of the TCR are indicated as open and solid boxes, respectively. The surrogate α chain of the pre-TCR is indicated as a hatched box.