TABLE 1.
Phosphorylation of Vav mediated by membrane receptors
| Receptora | Referenceb |
|---|---|
| Tyrosine kinase receptors | |
| c-Fms | 163 |
| c-Kit | 1 |
| EGF-R | 12, 86 |
| Flk-2 | 33 |
| IGF-1-R | 152 |
| Insulin-R | 151 |
| PDGF-R | 12 |
| TrkA | 90 |
| Receptors signaling via the Syk/Zap70 family | |
| BCR | 10 |
| CD28 | 3, 104 |
| FcγRI | 69 |
| FcɛRI | 86 |
| FcγRII | 69 |
| FcγRIII | 160 |
| Integrins | 21 |
| NK complexc | 5 |
| TCR | 12, 86 |
| Receptor signaling via the Src family | |
| CD19 | 154 |
| Receptors signaling via the Jak family | |
| c-Mpl | 31, 100, 102, 130 |
| Epo-R | 84 |
| G-CSF-R | 164 |
| GM-CSF-R | 89 |
| IL-2-R | 34 |
| IL-3-R | 89 |
| IL-5-R | 132 |
| IL-6-R | 78 |
| Prolactin R | 76 |
| Type I IFN-R | 119 |
| Receptors with uncharacterized kinases | |
| CD14 | 47 |
| CD2 | 121 |
| CD40 | 110 |
| CD43 | 115 |
| CD5 | 49 |
| G-coupled receptors | |
| PAR1 | 22 |
| Thrombin-R | 21 |
a
Receptors shown to phosphorylate Vav3 are underlined. IGF, insulin growth factor; IFN, interferon; PAR, protease-activated receptor.
b
For simplicity, only the first articles reporting the participation of Vav in a particular receptor pathway are included.
c
The receptor for the cytotoxic response of NK cells has not been identified yet. It is possible that it is not a single molecular entity but rather a set of membrane proteins (79).