Table 3.
Prevalence of virulence genes known or proposed to play a role in S. aureus pathogenicity in PJI predicted from SMg in this study using 90% identity and 90% sequence coverage.
| Virulence gene | Product | Approach | |
|---|---|---|---|
| Prokka annotation | VFDB annotation | ||
| aur | Zinc metalloproteinase aureolysin | 100 | 50 |
| clfA | Clumping factor A fibrinogen-binding protein | 35 | 25 |
| cna | Collagen adhesin precursor | 70 | 10 |
| fnbA | Fibronectin-binding protein A | 100 | 25 |
| hld | Delta-hemolysin | 100 | 100 |
| hlgA | Gamma-hemolysin chain II precursor | 100 | 100 |
| hlgB | Beta-hemolysin | 100 | 100 |
| hlgC | Gamma-hemolysin component C | 100 | 100 |
| sdrD | Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein | 65 | 25 |
| sdrE | Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein | 75 | 25 |
| spa | Immunoglobulin G binding protein A precursor | 100 | 60 |
| sspA | Serine protease; V8 protease; glutamyl endopeptidase | 100 | 100 |
| sspB | Staphopain cysteine proteinase SspB | 100 | 100 |
| sspC | Staphostatin B | 100 | 100 |
| hly/hla | Alpha-hemolysin precursor | 100 | 100 |