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. 2021 Oct 21;12:6120. doi: 10.1038/s41467-021-25731-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Analyses were performed using genetic associations with LDL-C, HDL-C, and TG from the Global Lipid Genetic Consortium (GLGC) with CHD events from the CardiogramPlusC4D Consortium. Drug targets are grouped by clinical phase according to the ChEMBL database. Blue indicates a beneficial effect on CHD risk and red a detrimental effect per SD difference with respect to the indicated lipid sub-fraction. Significant estimates are indicated with an asterisk (*). Co-localization of genetic effects on the relevant lipid sub-fraction and CHD at the same locus is indicated by a square around the cell.