Table 4.
Comparison between the post vaccine adverse effects after vaccination with BNT162b2 and ChAdOx1 as well as those after the first and the second doses of BNT162b2.
| First dose | First and second doses of BNT162b2* | |||||
|---|---|---|---|---|---|---|
| BNT162b2 | ChAdOx1 | P-value | 1st dose | 2nd dose | P-value | |
| Number | 2,601 (62.37) | 1569 (37.63) | 0.001 | 456 (100) | 456 (100) | 0.001 |
| Severity of the side effects | ||||||
| No side effects | 375 (14.42) | 62 (3.95) | 0.001 | 78 (17.11) | 63 (13.81) | 0.149 |
| Presence of side effects | 2,226 (85.58) | 1,507 (96.05) | 378 (82.89) | 392 (85.96) | ||
| Mild | 1,423 (63.92) | 454 (30.13) | 0.001 | 258 (56.57) | 164 (35.96) | 0.001 |
| Moderate | 616 (27.67) | 582 (38.62) | 94 (20.6) | 135 (29.61) | ||
| Severe | 171 (7.68) | 448 (29.73) | 23 (5.04) | 86 (18.85) | ||
| Critical | 16 (0.72) | 23 (1.53) | 3 (0.66) | 6 (1.32) | ||
| Duration of the side effects | ||||||
| didn't have | 375 (14.42) | 62 (3.95) | 0.001 | 78 (17.11) | 63 (13.81) | 0.246 |
| 1 day | 679 (30.50) | 474 (31.45) | 132 (34.92) | 126 (32.14) | ||
| 2 days | 877 (39.40) | 560 (37.16) | 156 (41.27) | 157 (40.05) | ||
| 3 days | 366 (16.44) | 258 (17.12) | 59 (15.61) | 61 (15.56) | ||
| 4 days | 100 (4.49) | 76 (5.04) | 10 (2.64) | 18 (4.59) | ||
| 5 days | 52 (2.34) | 54 (3.58) | 7 (1.85) | 4 (1.02) | ||
| 6 days | 11 (0.49) | 9 (0.60) | 1 (0.26) | 3 (0.77) | ||
| 7 days | 44 (1.98) | 23 (1.52) | 4 (1.06) | 8 (2.04) | ||
| > 7 days | 97 (4.36) | 53 (3.52) | 9 (2.38) | 15 (3.83) | ||
| Local reactions, n (%) | ||||||
| Pain | 2,088 (80.27) | 1,347 (85.85) | 0.001 | 355 (77.85) | 334 (73.57) | 0.132 |
| Swelling | 677 (26.03) | 393 (25.05) | 0.482 | 132 (28.95) | 137 (30.18) | 0.658 |
| Swollen lymph nodes | 98 (3.77) | 44 (2.80) | 0.097 | 22 (4.82) | 34 (7.49) | 0.094 |
| Systemic reactions, n (%) | ||||||
| Headache | 861 (33.10) | 948 (60.42) | 0.001 | 143 (31.36) | 194 (42.73) | 0.001 |
| Fever | 617 (23.72) | 1163 (51.75) | 0.001 | 103 (22.59) | 236 (51.98) | 0.031 |
| Chill | 303 (11.65) | 735 (46.85) | 0.001 | 46 (10.09) | 131 (28.85) | 0.001 |
| Palpitation | 193 (7.42) | 269 (17.14) | 0.001 | 19 (4.17) | 60 (13.22) | 0.001 |
| Joint pain | 735 (28.26) | 873 (55.64) | 0.001 | 28 (6.17) | 112 (24.56) | 0.001 |
| Muscle pain | 1,088 (41.83) | 1,100 (70.11) | 0.001 | 31 (6.83) | 162 (70.11) | 0.001 |
| Fatigue | 1,358 (52.21) | 1,354 (86.30) | 0.001 | 217 (47.59) | 198 (43.61) | 0.229 |
| Impaired concentration | 367 (14.11) | 463 (29.51) | 0.001 | 46 (10.09) | 103 (22.69) | 0.001 |
| Insomnia | 402 (15.46) | 430 (27.40) | 0.001 | 54 (11.84) | 43 (9.47) | 0.247 |
| Dizziness | 526 (20.2%) | 650 (41.4%) | 0.001 | 62 (13.6%) | 249 (54.8%) | 0.001 |
| Diarrhea | 164 (6.31) | 151 (9.62) | 0.001 | 19 (4.17) | 308 (67.84) | 0.001 |
| Abdominal pain | 182 (6.99) | 149 (9.50) | 0.004 | 14 (3.07) | 82 (18.06) | 0.001 |
| Chest pain | 204 (7.84) | 209 (13.32) | 0.001 | 20 (4.39) | 33 (7.27) | 0.063 |
| Breathlessness | 149 (5.73) | 53 (9.75) | 0.001 | 8 (1.75) | 18 (3.96) | 0.045 |
| Allergic reaction, n (%) | ||||||
| Rash | 75 (2.88) | 41 (2.61) | 0.067 | 9 (1.97) | 12 (2.64) | 0.501 |
| Itching | 233 (8.96) | 134 (8.54) | 0.645 | 33 (7.24) | 42 (9.25) | 0.269 |
| Swollen lips | 48 (1.85) | 32 (2.04) | 0.658 | 10 (2.19) | 8 (1.76) | 0.654 |
Data are showed as number (percentage). Chi-square test was used to calculate the p-value for the difference between the first dose of BNT162b2 and ChAdOx1 or comparing the first dose of BNT162b2 with the second dose.
*
The people who got the second dose of the vaccine (n = 456) were extracted from the total number of Pfizer-BioNTech vaccinees (n = 2601).