Table 2.

Criteria for considering studies for the review based on the population, intervention, comparator, outcomes, and study designs (PICOS) structure.

	Population	Intervention	Comparator	Outcomes	Study designs
Inclusion criteria	Aged ≥ 17 years oldwith SCI, neurogenic urinary incontinence and NDO refractory, an inadequate response or intolerance to oral anticholinergic drugs and so on.	BoNT-A into the detrusor and the trigone.	BoNT-A into the detrusor, excluding the trigone.	Impact on patient symptom score; impact on complete dryness rate; impact on change in number of incontinence episodes; impact on detrusor pressure at maximum flow rate; impact on volume at the first desire to void; impact in maximum cystometric capacity; impact on post-viod residual volume.	RCT
Exclusion criteria	Age <17 years old; an allergy to BoNT-A; Infection and pregnancy; mixed urinary incontinence; other causes of bladder outlet obstruction; previous intravesical Botox injection and so on.	Other therapy.	Other therapy.	Qualitative outcomes such as inadequate indicators and others;	Observational study, letters, comments, reviews, and animal experiment.

BoNT-A, onabotulinumtoxinA; RCT, randomized controlled trial; SCI, spinal cord injury; NDO, neurogenic detrusor overactivity.