Table 4.

18F-NaF PET’s diagnostic accuracy in ROD

Variables	AUC		Criterion	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
a. 18F-NaF PET strength to recognize high turnover/hyperparathyroid bone disease
18F-fluoride activity in the PET scan unified TMV-based	0.86		Cut-off > 0.055 Ml/min/Ml	82	100	88	100
PTH unified TMV-based	0.69		> 450 ng/ml	55	87	72	75
b. 18F-NaF PET strength to recognize low turnover/adynamic bone disease
18F-fluoride activity in the PET scan unified TMV-based		0.87	Cut-off < 0.038 Ml/min/Ml	100	70	100	50
18F-fluoride activity in the PET scan turnover -based		0.83	Cut-off < 0.038 Ml/min/Ml	63	80	57	83
PTH—unified TMV-based		0.78	< 185 ng/ml	67	85	89	57
PTH—turnover-based		0.68	< 185 ng/ml	31	80	42	71