Table 1.
Demographics, clinical information, and task performance.
| SZ (n = 30) | MDD (n = 30) | HC (n = 30) | P | |
|---|---|---|---|---|
| Age (years) | 27.23 ± 7.04 | 29.40 ± 8.87 | 27.27 ± 7.90 | 0.483 |
| Gender (men/women) | 14/16 | 12/18 | 12/18 | 0.835 |
| Education (years) | 13.90 ± 2.44 | 14.33 ± 2.45 | 15.20 ± 1.65 | 0.086 |
| Duration of illness (months) | 28.71 ± 31.14 | 26.71 ± 24.72 | – | – |
| PANSS | 72.1 ± 6.58 | – | – | – |
| HAMD | – | 25.2 ± 6.65 | – | – |
| HAMA | – | 17.5 ± 6.77 | – | – |
| Medicine (mg/day) | ||||
| Antipsychotics | 412.50 ± 181.20A | 150.00 ± 32.07A | – | – |
| Antidepressants | 41.90 ± 17.71B | 86.67 ± 7.93B | – | – |
| Anxiolytics | 5.30 ± 2.60C | 6.18 ± 0.53C | – | – |
| VTF performance (n) | 7.65 ± 2.33a,b | 9.53 ± 2.45 | 9.76 ± 1.83 | 0.001* |
| TOL performance | ||||
| Total responses (n) | 11.87 ± 5.34b | 12.43 ± 5.08c | 17.63 ± 3.75 | 0.000* |
| Correct responses (n) | 7.80 ± 5.25b | 9.40 ± 4.70c | 14.03 ± 4.93 | 0.000* |
| Accuracy (%) | 0.64 ± 0.22a,b | 0.75 ± 0.24 | 0.79 ± 0.22 | 0.020* |
| Average responses time (s) | 12.39 ± 7.43b | 10.57 ± 2.94c | 8.45 ± 2.18 | 0.008* |
PANSS, Positive and Negative Syndrome Scale; HAMD, Hamilton Depression Scale; HAMA, Hamilton Anxiety Rating Scale; SZ, Schizophrenia; MDD, Major depressive disorder; HC, Healthy control.
a
The difference between SZ and HC is significant.
b
The difference between SZ and MDD is significant.
c
The difference between MDD and HC is significant.
A
The chlorpromazine equivalent dose.
B
The imipramine equivalent dose.
C
The diazepam equivalent dose.
*
means that the difference is statistically significant.