Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 8;12:723224. doi: 10.3389/fphys.2021.723224

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Griffiths and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of coronavirus entry via the late endocytosis pathway. Upper panel, in the absence of TMPRSS2, virus is endocytosed and within the endosome-lysosome compartment low pH activates cathepsin (CTP) mediated cleavage of the spike protein triggering membrane fusion and release of viral RNA. Lower panel, 25-HC inhibits viral replication by binding to NPC1 and restricting cholesterol transport to the lysosome membrane and export, ultimately preventing membrane fusion and release of viral RNA.