TABLE 2.

Effects of vitamin B₆ and its metabolite, pyridoxal 5′-phosphate (PLP) on myocardial infarction (MI) induced arrhythmias and mortality in rats.

Parameters	Untreated MI	Vitamin B6 treated MI	PLP treated MI
ST segment, mV	0.18 ± 0.02	0.19 ± 0.01	0.10 ± 0.02*
QTc interval, ms	554 ± 26	566 ± 31	437 ± 22*
Time of onset of arrhythmias, s	45 ± 9.6	47 ± 8.4	125 ± 11.2*
Number of PVC, %	5.0	5.2	1.4*
Incidence of ventricular tachycardia, %	67	61	12*
Mortality within first day of MI, %	35	30	16*

Treatment of rats with or without vitamin B₆ (50 mg/kg, daily) or PLP (25 mg/kg, daily) was started 2 days before inducing MI by occluding the coronary artery. The electrocardiographic changes in ST segment, QTc interval, and PVC (premature ventricular contraction) and mortality were monitored during the first day of inducing MI. The data are taken from our paper (Dhalla et al., 2013). *P < 0.05 vs. untreated group.