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. 2021 Jun 8;29(10):3059–3071. doi: 10.1016/j.ymthe.2021.06.005

Figure 2.

Figure 2

Intranasally administered GM1 was delivered to mouse brain

(A) GM1 (0.5 or 5 mg/kg/day) was intranasally infused into GM2S-KO mice for 7 days. GM1 bands on TLC were visualized with cholera toxin B (CtxB)-HRP (CtxB has been frequently used as a probe of GM1). Intranasally infused GM1 (5 mg/kg/day) could be delivered to the cortical tissue (B and C) and substantia nigra (D and E) in the midbrain of GM2S-KO mice. Purple indicates GM1; blue indicates nuclear DAPI; green indicates tyrosine hydroxylase (TH). Scale bars, 50 μm (B) and 5 μm (D).