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. 2021 Oct 21;4:1206. doi: 10.1038/s42003-021-02725-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — SNP mutation types of thymine at position 4 (a) and adenine at position 6 (b) within canonical (“TNA”) branch point sequence motifs and other genomic features. The widths of differently colored bars indicate the proportion of substitution to the other three nucleotides. The number of substitutions observed in our variant catalogue is given in the middle of each differently colored bar. The Ti/Tv ratio for the features is indicated at the end of the bars. Values in the parenthesis are p values (<0.05 indicated in bold text) from pairwise Fisher’s exact tests comparing the Ti/Tv ratio of nucleotides within the BPS and other genomic features. For splice sites, analysis was limited to a splice site where the canonical sequence motif (GT and AG at 5′ and 3′ splice sites respectively) contains the studied residues.