Table 1.
Genes significantly associated with endometrial cancer risk as identified by S-MultiXcan and colocalization.
| Locus | Gene | Ntissue | P-value | Zmin | Zmax | Zmean | ZSD | PPAdipose Sub. | PPAdipose Vis. | PPOvary | PPVagina | PPUterus | PPWB |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3q21.3 | EEFSEC | 3 | 1.10E−06 | 2.98 | 5.07 | 4.08 | 1.05 | 0.85 | 0.85 | 0.01 | 0.09 | 0.02 | 0.88 |
| 6q22.31 | HEY2 | 1 | 9.94E−09 | −5.73 | −5.73 | −5.73 | NA | 0.00 | 0.00 | 0.89 | 0.01 | 0.02 | 0.00 |
| 15q21.2 | GLDN | 4 | 1.34E−12 | −2.02 | 3.65 | −0.23 | 2.62 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 |
| 15q21.2 | CYP19A1 | 2 | 9.52E−12 | 5.75 | 6.17 | 5.96 | 0.30 | 0.82 | 0.02 | 0.00 | 0.01 | NA | 0.28 |
| 17q11.2 | EVI2A | 3 | 1.50E−06 | −5.14 | −3.45 | −4.51 | 0.92 | 0.90 | 0.88 | 0.03 | 0.02 | 0.01 | 0.88 |
| 17q21.32 | SKAP1 | 2 | 7.27E−09 | −6.11 | −0.15 | −3.13 | 4.22 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.95 |
| 17q21.32 | SNX11 | 4 | 5.41E−07 | 3.49 | 5.38 | 4.63 | 0.83 | 0.03 | 0.03 | 0.03 | 0.02 | 0.03 | 0.02 |
The Bonferroni corrected P value threshold is 3.8 × 10−6 (accounting for 13,182 genes tested). Bolded findings have evidence of colocalization (PP > 0.8) in at least one tissue.
Ntissue number of tissues with available expression weights, Zmin minimum Z score from single tissue S-PrediXcan result, Zmax maximum Z score from single tissue S-PrediXcan result, Zmean mean Z score from single tissue S-PrediXcan result, ZSD standard deviation of Z score from single tissue S-PrediXcan result, PP posterior probability that endometrial cancer risk and eQTL variants from respective tissue colocalize, Adipose Sub. subcutaneous adipose, Adipose Vis. visceral omentum adipose, WB whole blood, NA not available.