Table 2.

Binding energy for IL6, VEGFA and TNF with compounds of Rhizoma Coptidis.

Mol ID	Molecule Name	Binding energy (kJ/mol)
		IL6	VEGFA	TNF
Positive control	Metformin	− 4.6	− 3.6	− 5.7
MOL000098	quercetin	− 6.9	− 5.9	− 6.9
MOL000622	Magnograndiolide	− 5.4	− 5.5	− 8.8
MOL000762	Palmidin A	− 7.6	− 6.8	− 7.6
MOL000785	palmatine	− 6.4	− 5.3	− 6
MOL001454	palmatine	− 6.9	− 5.9	− 6.9
MOL001458	coptisine	− 7.6	− 6.1	− 8.5
MOL002668	Worenine	− 6.8	− 6.3	− 7.3
MOL002894	berberrubine	− 6.6	− 5.6	− 7.8
MOL002897	epiberberine	− 7.3	− 5.9	− 6.6
MOL002903	(R)-Canadine	− 6.7	− 5.7	− 6.5
MOL002904	Berlambine	− 7.1	− 5.7	− 7.8
MOL002907	Corchoroside A_qt	− 6.2	− 5.4	− 6.4
MOL008647	Moupinamide	− 6.8	− 5.3	− 6.7
MOL013352	Obacunone	− 7.5	− 6.6	− 7.5