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. 2021 Oct 21;11:20866. doi: 10.1038/s41598-021-00286-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Grouping of identified COVID-19 infection-dependent metabolites into lipid classes. Comparative abundance profile of the identified subclasses of lipids per class in the plasma of uninfected and COVID-19-infected individuals. An over view of levels, as measured by peak area (Y- axis), of metabolites in COVID-19-infected and control samples as measured by LC–MS/MS IDA analysis. Each color line represents a metabolite as defined in the inclusion list, grouped into lipid subclass, and lipid class. (a) Analysis of observed changes in peak area of subclasses of the Cer (Y-axis) in uninfected (samples N1–N18) and COVID-19-infected plasma samples (X-axis, Samples Covid1–24, Covid 46–62). (b) Changes in the observed retention time of the subclasses of Cer across all samples. (c) Analysis of observed changes in peak area of subclasses of the PE, PG, PI, and PS class (Y-axis) in uninfected and COVID-19-infected plasma samples (X-axis). Each metabolite defined in the inclusion list is represented in a different color.

Grouping of identified COVID-19 infection-dependent metabolites into lipid classes. Comparative abundance profile of the identified subclasses of lipids per class in the plasma of uninfected and COVID-19-infected individuals. An over view of levels, as measured by peak area (Y- axis), of metabolites in COVID-19-infected and control samples as measured by LC–MS/MS IDA analysis. Each color line represents a metabolite as defined in the inclusion list, grouped into lipid subclass, and lipid class. (a) Analysis of observed changes in peak area of subclasses of the Cer (Y-axis) in uninfected (samples N1–N18) and COVID-19-infected plasma samples (X-axis, Samples Covid1–24, Covid 46–62). (b) Changes in the observed retention time of the subclasses of Cer across all samples. (c) Analysis of observed changes in peak area of subclasses of the PE, PG, PI, and PS class (Y-axis) in uninfected and COVID-19-infected plasma samples (X-axis). Each metabolite defined in the inclusion list is represented in a different color.