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. 2021 Oct 21;11:20799. doi: 10.1038/s41598-021-00268-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Redundancy analysis of the top 10 HUB genes. The essential role of indicated HUB genes in breast cancer cell survival was analyzed via DepMap, (https://depmap.org/portal/), which was established from CRISPR and RNAi screening data. (A) Redundancy analysis of ten genes in total cells lines. (B) The CERES dependency score of ten genes in breast cancer cells. A lower CERES score indicates a higher likelihood that the gene of interest is essential in a given cell line. A score of 0 indicates a gene is not essential (dotted line); − 1 is comparable to the median of all pan-essential genes (red line).