Table 1.
Trial 1 (P49) |
Trial 2 (P71) |
||||||||
---|---|---|---|---|---|---|---|---|---|
ID | Genotype | 1a | 1b | 1c | Mean | 2a | 2b | 2c | Mean |
3336 | iCKO | 56 | 76 | 65 | 66 | 71 | 70 | 65 | 69 |
3337 | iCKO | 57 | 67 | 122 | 82 | 52 | 62 | 73 | 62 |
3334 | iCKO | 125 | 54 | 91 | 90 | 78 | 94 | 60 | 77 |
3343 | iCKO | 38 | 68 | 77 | 61 | 48 | 94 | 60 | 67 |
3345 | iCKO | 76 | 111 | 107 | 98 | 49 | 100 | 111 | 87 |
Mean | 70 | 75 | 92 | 79 | 60 | 84 | 74 | 72 | |
3338 | control | 112 | 80 | 134 | 109 | 112 | 76 | 108 | 99 |
3339 | control | 76 | 79 | 106 | 87 | 83 | 73 | 106 | 87 |
3340 | control | 92 | 118 | 50 | 87 | 61 | 120 | 111 | 97 |
3341 | control | 86 | 82 | 118 | 95 | 89 | 111 | 128 | 109 |
3342 | control | 112 | 89 | 96 | 99 | 106 | 130 | 99 | 112 |
Mean | 96 | 90 | 101 | 95 | 90 | 102 | 110 | 101 |
At P49, the difference between genotypes was not statistically significant (F = 4.08, df = 1 and 8, p = 0.078). At P71, the difference between genotypes was statistically significant (F = 23.6, df = 1 and 8, p = 0.0013). Connexin 26 depletion led to a slight decrease in vestibular function.