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. 2021 Oct 8;12:724372. doi: 10.3389/fphys.2021.724372

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Copyright © 2021 Hou, Bai, Shen, de Langen, Li, Lal, dos Remedios, Baddeley, Ruygrok, Soeller and Crossman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Super-resolution imaging of RyR clusters in donor and IDCM human hearts. (A) RyR clusters in Donor myocyte. (B) RyR clusters in IDCM myocyte. (C) Binary mask of “(A)” segmented into TT (green), Sl (red), and Corb regions (white). (B) RyR clusters in IDCM myocyte. (D) Binary mask of “(B)” segmented into TT, Sl, and Corb regions. (E) Mean RyR clusters size in NF and IDCM hearts. (F) Mean RyR intercluster distance in NF and IDCM hearts. Symbols of the same colour in “(E,F)” are from the same heart. (G) Mean number of JPH counts per RyR cluster. (H) Total number of JPH counts per RyR cluster. Groups linked with a line are significantly different in post-hoc pairwise comparison at either p < 0.05, p < 0.01, and p < 0.001 as indicated by ^*, ^**, and ^*** respectively. LME model was used to test for the effects of disease status (IDCM, NF) and cell region (t-tubules, sarcolemma, corbular) and random effects were in the heart. P-values reported are post-hoc comparisons of marginal means using a Sidak test for multiple comparisons.