TABLE 1.
Tumor-derived extracellular vesicles (EVs) and their effect on macrophage polarization based on their cargo.
| Polarization | Tumor source of EVs | Key cargo | References |
| Ml | Oral squamous cell carcinoma (OSCC) | THBS1 | Xiao et al., 2018 |
| Breast cancer | MiRNA-16 | Jang et al., 2013 | |
| Pancreatic ductal adenocarcinoma (PDAC) | MiRNA-155, miRNA-125b | Su et al., 2016 | |
| Colorectal cancer (CRC) | MiRNA-21 | Popēna et al., 2018; Shao et al., 2018 | |
| M2 | Triple negative breast cancer (TNBC) | CD63 | Piao et al., 2017 |
| Hepatocellular carcinoma (HCC) | LncRNAs | Li et al., 2018 | |
| Lung cancer | MiR-103a, TRIM59 | Hsu et al., 2018; Liang et al., 2020; Pritchard et al., 2020 | |
| Epithelial ovarian cancer | MiRNA-222 | Ying et al., 2016 | |
| Glioblastoma (GBM) | Focal adhesion proteins, leukocyte transendothelial migration proteins, miRNA-1246 | Gabrusiewicz et al., 2018; Qian et al., 2020 | |
| Oral squamous cell carcinoma (OSCC) | MiRNA-21, miRNA-29a-3p | Li et al., 2016; Cai et al., 2019 | |
| Colorectal cancer (CRC) | MiRNA-203, miRNA-934 | Takano et al., 2017; Wang et al., 2020; Zhao et al., 2020 |