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. 2021 Oct 8;12:735165. doi: 10.3389/fphar.2021.735165

FIGURE 3.

FIGURE 3

Effect of TMZ on GFAP expression in the hippocampi of rats with Li/PIL-induced seizures as indicated by immunohistochemistry (×400 original magnification). Normal control rats (A), Normal + TMZ rats (B), Li/PIL control rats (C), and TMZ + Li/PIL rats (D). Area % of GFAP (E). Values are expressed as mean of three animals ± SD. Two-way ANOVA followed by the Tukey–Kramer post-hoc test was used for statistical analyses of data. **Significantly different from the normal control group (Saline) at p < 0.01; ****Significantly different from the normal control group (Saline) at p < 0.0001; @@@@Significantly different from the Li/PIL control group at p < 0.0001.