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. 2021 Oct 8;12:706951. doi: 10.3389/fimmu.2021.706951

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Copyright © 2021 Shimba, Ejima and Ikuta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucocorticoids in circadian rhythm and dietary restriction induce the migration of naïve and memory T cells into the spleen and bone marrow. GCs induced by circadian rhythm promote the homing of naïve T cells into secondary lymphoid organs from peripheral blood by inducing the expression of IL-7R and CXCR4. The T cell accumulation induces strong immune responses by activated CD8 T and follicular helper T (Tfh) cells against bacterial infection and soluble antigens. GCs induced by dietary restriction trigger the egress of memory CD8 T cells from secondary lymphoid organs and homing into the bone marrow. The accumulation in the bone marrow enhances the survival and response of memory CD8 T cells.