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. 2021 Oct 8;11:681905. doi: 10.3389/fonc.2021.681905

Table 2 .

Correlations between AAPR and clinicopathological characteristics in the training cohort.

Characteristics AAPR < 0.583 (n = 233) AAPR ≥ 0.583 (n = 313) p-value
Age (y) <0.001
 <50 82 (35.2) 221 (70.6)
 ≥50 151 (64.8) 92 (29.4)
Menopause <0.001
 Yes 133 (57.1) 79 (25.2)
 No 100 (42.9) 234 (74.8)
Chemotherapy cycles 0.924
 3 8 (3.4) 9 (2.9)
 4 208 (89.3) 280 (89.5)
 5-8 17 (7.3) 24 (7.7)
Histological type 0.007
 Ductal 219 (94.0) 304 (97.1)
 Lobular 2 (0.9) 6 (1.9)
 Others 12 (5.2) 3 (1.0)
Tumor size 0.188
 T1 23 (9.9) 39 (12.5)
 T2 169 (72.5) 204 (65.2)
 T3 41 (17.6) 70 (22.4)
Clinical nodal status 0.960
 Negative 100 (42.9) 135 (43.1)
 Positive 133 (57.1) 178 (56.9)
Histological Grade 0.189
 I 21 (9.0) 16 (5.1)
 II 171 (73.4) 236 (75.4)
 III 41 (17.6) 61 (19.5)
ER 0.277
 Negative 94 (40.3) 112 (35.8)
 Positive 139 (59.7) 201 (64.2)
PR 0.260
 Negative 126 (54.1) 154 (49.2)
 Positive 107 (45.9) 159 (50.8)
HER2 status 0.396
 Negative 127 (54.5) 182 (58.1)
 Positive 106 (45.5) 131 (41.9)
Ki67 expression (%) 0.608
 <14 74 (31.8) 93 (29.7)
 ≥14 159 (68.2) 220 (70.3)
Molecular subtypes 0.045
 Luminal 97 (41.6) 133 (42.5)
 Luminal/HER2 45 (19.3) 78 (24.9)
 HER2 61 (26.2) 53 (16.9)
 TNBC 30 (12.9) 49 (15.7)
Response evaluation 0.030
 pCR 23 (9.9) 51 (16.3)
 Non-pCR 210 (90.1) 262 (83.7)

ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor 2; AAPR, albumin-to-alkaline phosphatase ratio; pCR, pathologic complete response.