Table 3.
Univariate analysis for factors associated with pCR in the training cohort.
| Characteristics | Non-pCR (n = 472) | pCR (n = 74) | p-value |
|---|---|---|---|
| Age (y) | 0.306 | ||
| <50 | 266 (56.4) | 37 (50.0) | |
| ≥50 | 206 (43.6) | 37 (50.0) | |
| Menopause | 0.561 | ||
| Yes | 181 (38.3) | 31 (41.9) | |
| No | 291 (61.7) | 43 (58.1) | |
| Chemotherapy cycles | 0.947 | ||
| 3 | 15 (3.2) | 2 (2.7) | |
| 4 | 422 (89.4) | 66 (89.2) | |
| 5-8 | 35 (7.4) | 6 (8.1) | |
| Histological type | 0.609 | ||
| Ductal | 453 (96.0) | 70 (94.6) | |
| Lobular | 7 (1.5) | 1 (1.4) | |
| Others | 12 (2.5) | 3 (4.1) | |
| Tumor size | 0.007 | ||
| T1 | 46 (9.7) | 16 (21.6) | |
| T2 | 325 (68.9) | 48 (64.9) | |
| T3 | 101 (21.4) | 10 (13.5) | |
| Clinical nodal status | <0.001 | ||
| Negative | 181 (38.3) | 54 (73.0) | |
| Positive | 291 (61.7) | 20 (27.0) | |
| Histological Grade | 0.011 | ||
| I | 26 (5.5) | 11 (14.9) | |
| II | 358 (75.8) | 49 (66.2) | |
| III | 88 (18.6) | 14 (18.9) | |
| ER | <0.001 | ||
| Negative | 164 (34.7) | 42 (56.8) | |
| Positive | 308 (65.3) | 32 (43.2) | |
| PR | <0.001 | ||
| Negative | 226 (47.9) | 54 (73.0) | |
| Positive | 246 (52.1) | 20 (27.0) | |
| HER2 status | 0.431 | ||
| Negative | 264 (55.9) | 29 (39.2) | |
| Positive | 208 (44.1) | 45 (60.8) | |
| Ki67 expression (%) | <0.001 | ||
| <14 | 158 (33.5) | 9 (12.2) | |
| ≥14 | 314 (66.5) | 65 (87.8) | |
| Molecular subtypes | <0.001 | ||
| Luminal | 210 (44.5) | 20 (27.0) | |
| Luminal/HER2 | 109 (23.1) | 14 (18.9) | |
| HER2 | 99 (21.0) | 15 (20.3) | |
| TNBC | 54 (11.4) | 25 (33.8) | |
| ALB | 0.765 | ||
| <40 | 178 (37.7) | 34 (45.9) | |
| ≥40 | 294 (62.3) | 40 (54.1) | |
| ALP | 0.823 | ||
| <100 | 430 (91.1) | 68 (91.9) | |
| ≥100 | 42 (8.9) | 6 (8.1) | |
| AAPR | 0.030 | ||
| <0.583 | 210 (44.5) | 23 (31.1) | |
| ≥0.583 | 262 (55.5) | 51 (68.9) |
ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor 2; ALB, albumin; ALP, alkaline phosphatase; AAPR, albumin-to-alkaline phosphatase ratio; pCR, pathologic complete response.