Table 4.

Multivariate analysis for factors associated with pCR in the training cohort.

Characteristics	Crude OR (95%CI)	p-value	Adjusted OR (95%CI)	p-value
Tumor size
T1	Reference		Reference
T2	0.425 (0.233-0.809)	0.009	0.355 (0.168-0.752)	0.007
T3	0.285 (0.120-0.675)	0.004	0.237 (0.091-0.620)	0.003
Clinical nodal status
Negative	Reference		Reference
Positive	0.230 (0.134-0.398)	<0.001	0.288 (0.162-0.513)	<0.001
Histological grade
I	Reference		Reference
II	0.324 (0.150-0.696)	0.004	0.256 (0.105-0.624)	0.003
III	0.376 (0.152-0.927)	0.034	0.247 (0.087-0.702)	0.009
ER
Negative	Reference		Reference
Positive	0.406 (0.247-0.667)	<0.001	0.789 (0.393-1.584)	0.505
PR
Negative	Reference		Reference
Positive	0.340 (0.198-0.586)	<0.001	0.462 (0.220-0.971)	0.041
Ki67 expression (%)
<14	Reference		Reference
≥14	3.634 (1.764-7.487)	<0.001	3.334 (1.534-7.229)	0.002
AAPR
<0.583	Reference		Reference
≥0.583	1.777 (1.052-3.004)	0.032	2.228 (1.246-3.986)	0.007

ER, estrogen receptor; PR, progesterone receptor; AAPR, albumin-to-alkaline phosphatase ratio; pCR, pathologic complete response.