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. 2021 Oct 8;12:705827. doi: 10.3389/fendo.2021.705827

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Copyright © 2021 Zhang, Xiao, Zheng, Li, Yu, Ping, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of maternal HFD activated the gene methylation of Acaa2, Acsl1, and Cox7a1 promoter in male offspring BAT. Diagram showed the CpG island region in promoters and transcriptional starting site (TSS) shores of (A) Acaa2, (C) Acsl1, and (E) Cox7a1. The methylation changes of (B) Acaa2, (D) Acsl1, (F) Cox7a1 quantified by MeDIP-qPCR in BAT. Values represent the mean ± SEM, n = 8 each group. P values represent significance in the main effect for each source of variation (diet or prenatal exposure) as calculated by two-way ANOVA: **P < 0.01 offspring diet effect, ^## P < 0.01 maternal diet effect. NC, normal control; DIO, diet-induced obesity; CD, control diet; HFD, high-fat diet.