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. 2021 Oct 8;12:705827. doi: 10.3389/fendo.2021.705827

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Copyright © 2021 Zhang, Xiao, Zheng, Li, Yu, Ping, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism by which maternal HFD disrupts brown adipose tissue (BAT) fatty acid oxidation (FAO) and thermogenesis in male offspring. Fatty acids (FAs) enter brown adipocytes and are activated by acyl-CoA sythetases, including Acsl1, to form acyl-CoAs. Then acyl-CoAs were catabolized to acetyl-CoAs by acyl-CoA dehydrogenases, such as Acaa2. Maternal HFD active the methylation of offspring BAT FAO related enzymes, such as Acsl1 and Acaa2. Meanwhile, Cox7a1 gene methylation in offspring BAT was also active by maternal HFD. To sum up, maternal HFD disturbs the BAT FAO and thermogenesis through activated specific gene DNA methylation. FA, fatty acid.