Table 4.
The enriched KEGG pathway with differentially methylated genes in DIO-CD offspring vs NC-CD offspring (P < 0.05).
| Term ID | Term name | Gene Count | Fold Enrichment | P value | Genes |
|---|---|---|---|---|---|
| mmu04390 | Hippo signaling pathway | 16 | 2.698 | 8.02 x 10-4 | CRB2, WWC1, FZD6, BMP8A, FZD8, FZD10, CSNK1E, LIMD1, GDF7, SOX2, WNT6, PPP2R1B, PPP2R2B, CDH1, CTNNA1, TEAD3 |
| mmu04630 | Jak-STAT signaling pathway | 14 | 2.459 | 0.0044 | OSM, PIK3CD, OSMR, PIAS2, IL22RA1, SOCS3, IFNE, LEPR, IFNK, EP300, JAK2, IL13RA1, SOCS5, CRLF2 |
| mmu03420 | Nucleotide excision repair | 7 | 4.052 | 0.0069 | DDB1, POLD3, ERCC4, CCNH, GTF2H1, GTF2H5, RBX1 |
| mmu04310 | Wnt signaling pathway | 13 | 2.348 | 0.0091 | CAMK2D, ROCK2, CTBP1, FZD6, FZD8, FZD10, CSNK1E, RBX1, PPP3CA, WNT6, PPP3CB, CSNK2B, EP300 |
| mmu04360 | Axon guidance | 12 | 2.369 | 0.0121 | SEMA6B, EFNB2, EPHA4, PPP3CA, PPP3CB, CDK5, ROCK2, SLIT2, PLXNC1, PTK2, ROBO1, EPHB3 |
| mmu04920 | Adipocytokine signaling pathway | 8 | 2.830 | 0.0220 | SOCS3, STK11, G6PC, ACSL1, TRADD, LEPR, JAK2, PCK2 |
| mmu00230 | Purine metabolism | 14 | 1.992 | 0.0231 | GUCY1A3, RRM1, PDE4C, ENTPD8, NME4, HPRT, HDDC3, POLD3, NT5E, ADCY9, POLR3D, PDE4B, POLR1D, POLR3G |
| mmu03022 | Basal transcription factors | 6 | 3.473 | 0.0277 | GTF2A1L, TBP, CCNH, GTF2H1, TAF9B, GTF2H5 |
| mmu04152 | AMPK signaling pathway | 11 | 2.189 | 0.0282 | CCNA1, STK11, G6PC, PPP2R1B, RAB14, CAB39L, PPP2R2B, PPP2R5B, LEPR, PIK3CD, PCK2 |
| mmu04114 | Oocyte meiosis | 10 | 2.274 | 0.0310 | PPP3CA, PPP3CB, CAMK2D, ADCY9, PPP2R1B, STAG3, PPP2R5B, ANAPC5, CPEB2, RBX1 |