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GQD alleviated the intestinal barrier function of T2DM rats. Expression levels of (A) ZO-1, (B) occludin, and (C) claudin-1 in the jejunum, ileum, and colon after treatment for 12 weeks. Values are expressed as means ± SE. Differences were assessed by ANOVA: **p < 0.01, *p < 0.05. ZO-1: zonula occludens-1. The fold over control means the fold change differences relative to DM based on 2(-delta delta CT) score.
