Table 1.
Drugs used to target tumor metabolism.
| Pathway | Inhibitor | Target molecule | Clinical trial | References |
|---|---|---|---|---|
| Glycolysis | BAY-876 | GLUT1 | Preclinical | (68) |
| Glycolysis | Apple polyphenol phoretin (Ph) | GLUT2 | Preclinical | (69) |
| Glycolysis | Gen-27 | Hexokinase II | Preclinical | (70) |
| Glycolysis | Silibinin | GLUT1 | in vitro | (71) |
| Glycolysis | Butyrate | PKM2 | Preclinical | (72) |
| TCA | Butyrate | SIRT3 | Preclinical | (73) |
| Glutaminolysis | l-γ-glutamyl-p-nitroanilide (GPNA) | ASCT2/SLC1A5 | Preclinical | (27) |
| Glycolysis | Oxamate | LDH-A, aspartate aminotransferase | Preclinical | (74) |
| Glycolysis | Galloflavin | LDH-A | Preclinical | (75) |
| Glycolysis | Lonidamide | Hexokinase II | Phase II | (76) |
| Lipid synthesis | Orlistat | Fatty acid synthase | Preclinical | (77) |